
Short answer: Three medications are FDA-approved to treat opioid use disorder: methadone, buprenorphine, and naltrexone. Each works differently, but all are most effective when combined with counseling and structured treatment rather than used alone.
- Methadone, buprenorphine, and naltrexone are the three medications approved by the FDA for opioid use disorder.
- Methadone and buprenorphine reduce withdrawal symptoms and cravings by acting on opioid receptors.
- Naltrexone works differently, blocking opioid receptors so opioids cannot produce their usual effect.
- Medication is most effective as part of a full treatment plan that includes therapy and support.
- The right medication, if any, depends on someone’s history, health, and treatment goals.
- This approach is often called medication-assisted treatment, or MAT.
The Three FDA-Approved Medications for Opioid Treatment

| Medication | How It Works |
|---|---|
| Methadone | A long-acting opioid agonist that reduces cravings and withdrawal without producing the same high, dispensed through licensed clinics. |
| Buprenorphine | A partial opioid agonist that eases withdrawal and cravings with a lower risk profile, often prescribed as Suboxone. |
| Naltrexone | An opioid blocker that prevents opioids from producing their effect, used after detox is complete. |
Why Medication Alone Is Not the Full Answer
Medications for opioid use disorder are proven to reduce overdose risk and support long-term recovery, but they work best as one part of a broader treatment plan. Medication can stabilize the physical side of addiction, while therapy addresses the underlying reasons someone turned to opioids in the first place.
This combined approach, often called medication-assisted treatment or MAT, has strong support in addiction research precisely because it treats both the biology and the psychology of addiction together.
How Liberty Approaches Opioid Treatment
At Liberty, opioid treatment starts with a safe medical detox, where our clinical team evaluates whether medication support makes sense for your situation. From there, clients move into our 60-day opioid addiction treatment program, which combines any needed medication management with trauma-informed therapy.
Whether the opioid involved is fentanyl, prescription pain medication, or heroin, our team builds a treatment plan around the individual, not a one-size-fits-all protocol.
Is Medication-Assisted Treatment Right for You?
Not everyone needs medication as part of their recovery, and that decision should be made with a clinical team that knows your full history. What matters most is finding a treatment plan that gives you the best chance at lasting recovery, whether that includes medication or not.
Opioid Treatment Built Around You
Liberty offers medical detox and a 60-day residential program in American Fork. Liberty accepts Medicaid and most Utah insurance plans.
Frequently Asked Questions
What medications are used in opioid treatment?
The three FDA-approved medications are methadone, buprenorphine, and naltrexone. Each works differently, and the right choice depends on individual health history and treatment goals.
Is methadone or buprenorphine better?
Neither is universally better. Methadone is dispensed through licensed clinics and can be a strong option for more severe dependence, while buprenorphine can often be prescribed more flexibly with a lower risk profile.
Do I have to take medication to recover from opioid addiction?
No. Medication is one option, not a requirement. Many people recover successfully with therapy and structured treatment alone, while others benefit from medication support.
How long do people stay on opioid addiction medications?
This varies widely by individual. Some people use medication for a defined period during early recovery, while others continue longer-term under medical supervision.
Is medication-assisted treatment considered trading one addiction for another?
No. When properly prescribed and monitored by a medical provider, these medications do not produce the same high as opioid misuse and are considered an evidence-based part of recovery, not a replacement addiction.
Does Liberty offer medication-assisted treatment?
Liberty evaluates each client’s history during medical detox to determine whether medication support fits their treatment plan, combined with trauma-informed therapy throughout our 60-day residential program.






